Page 56 - MemoriaCIBER2019-ENG

56
CIBER Annual report 2019
Preventive and therapeutic strategies in regenerative medicine,
cell therapy and gene therapy
It has been described that, during the development of type 1 diabetes, there is an increase in the renewal of pancreat- ic alpha cells, with the aim of maintaining their population or increasing the mass of beta cells, via transdifferentiation of these alpha cells. (Bru-Tari et al., Sci Rep. 2019).
The absence of the PTP-1B protein has been reported to increase the production of VEGF-A by pancreatic islets, im- proving their revascularization and increasing their survival after transplantation (Figueiredo et al., Sci Transl Med. 2019).
Knowledge of the three-dimensional architecture of the chromatin of the pancreatic islets is helping to understand the genetics of type 2 diabetes (Miguel-Escalada et al., Nat Genet. 2019).
The presence of ductal cells in pancreatic islet preparations has been established to be detrimental to the functional- ity of transplanted islets (Marín-Cañas et al., PLoS One 2019).
Application of new technologies
to the treatment of diabetes
Learning algorithms have been developed, which use data from the blood glucose of the patients to effectively pre- vent the appearance of postpandrial hypoglycemia in insulinised patients (Oviedo et al., Comput Methods Programs Biomed. 2019).
PROGRAMME 3. Cellular and molecular mechanisms iinvolved in the development and progression of type 2 diabetes and identification of new therapeutic targets.
Coordinator: Antonio Zorzano Olarte
Inflammation as a pathogenic process
in diabetes mellitus: role of the adipose tissue and interaction with other tissues or organs
The succinate receptor SUCNR1 has been shown to control the anti-inflammatory programme in the macrophage by regulating the metabolic response to obesity (Keiran et al., Nat Immunol. 2019). Two CIBERDEM groups have collabo- rated in this study, as well as other CIBER areas. Various patents have been applied for (EP19382564.3, PCT / EP2019 / 051157).
Identification of molecular mechanisms
and new therapeutic targets for the development of personalised early interventions in diabetes mellitus
The participation of the protein Mitofusin 2 in the development of chronic liver disease has been described through a mechanism that involves the transfer of phosphatidylserine from the endoplasmic reticulum to the mitochon- dria (Hernández-Álvarez et al., Cell 2019). This allows the development of insulin resistance and the development of non-alcoholic steatohepatitis to be related within the same pathological process. The study has been developed in collaboration with various CIBERDEM groups and other CIBER areas.